Large-scale tectonic magmatism and extensive gold mineralization have occurred in the eastern North China Craton (NCC) (Jiaodong and Liaodong peninsulas) since Mesozoic, which indicated that the region experienced decratonization process. The genesis type of granites evolved from S-type to I-type and A-type during Late Jurassic to Early Cretaceous, and thus reflects the evolution of geodynamics in the Late Mesozoic, indicating the varied subduction process of the Paleo-Pacific Plate (PPP) and the craton destruction. The evolution of geochemical features shows that the mantle beneath the Jiaodong Peninsula evolved from EM-II in Jurassic to EM-I in Early Cretaceous, demonstrating that the mantle switched from enriched to depleted. The gold of decratonic gold deposits in Jiaodong Peninsula mainly comes from the lithospheric mantle domains metasomatized by fluids derived from the metamorphism and dehydration of the subducted slab in the mantle transition zone. The rapid decomposition of minerals leads to the concentrated release of ore-forming fluids, and this process leads to the explosive gold mineralization during the craton destruction. Extensive magmatic uplift and extensional structures, triggered by the craton destruction in Early Cretaceous formed the extensional tectonic system, providing space for the decratonic gold deposits in Jiaodong Peninsula.