1. College of Earth Sciences, Jilin University, Changchun 130061, China;
2. The Fifth Geological Group Limited Liability Company of Liaoning Province, Dashiqiao 115100, Liaoning, China;
3. College of Resources, Hebei University of Geosciences, Shijiazhuang 050031, China

Tenige'ertu lead-zinc deposit is located in the southern Great Xing'an Range, which is a typical skarn deposit in Huanggang-Ganzhuermiao metallogenic belt. The deposit occurred in Huanggangliang Formation, and the hydrothermal ore-forming process can be divided into two periods and five stages. Fluid inclusion study indicates that there existed three types of inclusions in the skarn period ore-forming fluids, including SL, VL and LV types, whereas the ore-forming fluids of quartz-sulfide period have two types of inclusion, including VL and LV types. The H and O isotopes studies indicate that the δD_V-SMOW and δ¹⁸O_H2O values in skarn period are -114.5×10^-3 to -109.8×10^-3 and 2.6×10^-3 to 3.8×10^-3, respectively, and are -140.2×10^-3 to -120.7×10^-3 and -11.4×10^-3 to -0.5×10^-3, respectively in quartz-sulfide period, from quartz and calcite. This suggests that the ore-forming fluids in skarn period are mainly magmatic water, while those in quartz-sulfide period have a mixed magmatic-meteoric origin. The δ³⁴S_V-CDT values of pyrites, sphalerites and galenas are 0.7×10^-3 to 4.8×10^-3 (mean=2.01×10^-3), indicating a deep source.