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The authors discussed the Mesozoic distribution characteristics and hydrocarbon exploration direction in western depression zone of East China Sea shelf basin��The results indicate that��the Mesozoic strata are widely distributed with great thickness(>6 000 m in max)��and mainly developed in southern area��The Cretaceous sediments are distributed in Changjiang sag��Haijiao lower uplift��Oujiang sag��Minjiang sag and Taibei lower uplift��and the Jurassic sediments are mainly distributed in Minjiang sag��Minjiang sag has great thickness in Mesozoic with good source rocks and develops local structural trap��which has both regional and local seals with superior source-reservior-seal condition��Therefore��the Minjiang sag is the most in exploration prospect area in western depression zone of East China Sea shelf basin��