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The overlying strata of building foundation in Guangdong coastal areas are silty soil��mud��muddy soil contains gravel sand��gravel sand��strong and medium weathered granite��and with corrosive groundwater and complex geological conditions. Taking the foundation of 1# and 2# units desulphurize engineering technology building of Zhuhai power plant as example��the authors introduced the applicaton of large diameter pile foundation engineering in this area systematically��and analyzed the design and calculation of lager diameter pile foundation engineering�� and the technical points��technical difficulties and quality guarantee measures of punch pile foundation engineering. The reliability and security of this foundation engineering has been verified through the detection by relevant departments. The successful application of this project provides direct practical data for large diameter pile foundation engineering application in the coastal areas of South China.